Yes that would work amazingly well. Like, basically it'd be a canon AU in which Obi-Wan decided to get Padmé right away instead of fighting Anakin. This has the consequences of both Padmé being alive and Anakin not going Full Vader TM (and he never told Obi-Wan he hated him). So it's Obi-Wan & Padmé on the run, possibly with the kids? or maybe they don't manage to convince anyone that Padmé died but they did manage to convince people the kids are dead while they are in fact with the Organas and Skywalkers? idk but ANYWAY Padmé is running the Resistance and they keep running into Anakin and keep trying to turn him back to the Light while Anakin is all "WE CAN RULE THE GALAXY TOGETHER" and no one is getting much of anywhere (except that Anakin is more and more not seeing why he even listens to Palpatine, because Palpatine isn't even teaching him Force Lightning >:[ ). Eventually "Obi-Wan & Padmé on the run" turns into "Obi-Wan/Padmé on the run" but it's kind of messed up, because even though they love and care about each other they are also pointedly Not Talking About Anakin. Then they meet Anakin again and Anakin finds out and blows his fuse (even though he's been having sort of hate sex with Obi-Wan for years now) because how could Padmé?! And how could Obi-Wan?! And NOW they have the big fight with lightsabers and pyrotechnics. At one point Anakin says "If you say this isn't about me, I'll kill you" to Obi-Wan and means it. The force of it takes him by surprise. He never knew he hated Obi-Wan so much; he never knew he loved Obi-Wan so much. (Jedis are universally Bad At Feelings, but Anakin is on another level entirely.) Obi-Wan replies with "It is absolutely about you". That puts Anakin off-balance and lets Obi-Wan take the upper-hand again. Then the three of them have a serious conversation. THEN I GUESS THEY KILL PALPATINE AND RULE THE GALAXY IDK

That's how I'd do it if I were to write it WHICH I AM NOT